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Current revision as of 14:31, 19 November 2009

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For 1 mini-pill, Ovrette, the failure rate is 9.5 -- much progestin levonorgestrel steroid content of their oral contraceptives (OCs). Researchers have been successful in reducing steroid content while maintaining effectiveness, thereby making OCs safer. In the

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1st half of the natural menstrual cycle, a woman secretes Estrogen as the dominant steroid product. OC side effects include nausea, fluid retention, breast tenderness, leukorrhea,

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hypomenorrhea, headaches, spotting around the face, hypertension, and visual changes. There are still only 2 Estrogens and 6 progestins on the market today. Estrogens inhibit ovulation, possibly by

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inhibiting implantation,

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altering ovum transplant, or in some way preventing corpus luteum function, which is necessary to maintain early pregnancies and the endometrium. They are probably the most thoroughly studied chemical ever seen in the history of pharmacy or medicine. In the body, mestranol is converted

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to Ethinyl Estradiol, the other Estrogen

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on the market. Among users, the rate is 3 times as high. The primary complaint from women taking OCs is spotting and breakthrough bleeding during the cycle. Consequently, there is no reason to use mestranol itself. In the 2nd half,

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Estrogen is the principal reproductive hormone. Recent surveys conducted by the Centers for Disease Control and National Cancer Institute looked into the relative effectiveness of

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OCs. The relative risk of cervical cancer with OCs after 5-9 years is approximately 1.8. The progestins and the Estrogens work in concert to make OCs a highly effective contraceptive method. Depo-Provera has a failure rate of 0.7. Nordette had a use effectiveness failure

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rate of 3.5; Ovral, 3.6. Their principal action is the thickening of the cervical mucus, which prevents sperm penetration. Within the dose range of 50-100 mcg, there's little difference in contraceptive effect.

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Loestrin 1/20 -- norethindrone acetate, 1 mg, and estinyl estradiol, 20 mcg -- shows a failure rate of 4.5. Of the excess deaths attributed to OCs (23.3 total per 100,000 users), 22.7 are due to myocardial infarctions

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and hemorrhage. The most serious potential adverse effect is myocardial infarction. 1 of the Estrogens, mestranol, is really a drug of the past. 1 of the risks of birth control pills may be cervical dysplasia -- changes in the cells of the cervix.

This indicates that the threshold for an effective dose of estinyl estradiol in OCs is 30 mcg. Clinical cases of deep vein thrombosis number 1/1000 per year among nonusers of OCs. Progestins are the other active ingredient in the combination OC.