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The antimuscarinic activity in serum measured as atropine equivalents was 2.7 /- 0.4 (S.E.M.) ng/ml in Amitriptyline

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( Elavil ) patients and 1.1 /- 0.2 ng/ml in doxepin patients. To determine the effect of Atorvastatin ( Lipitor ) on blood rheology in patients with familial hypercholesterolemia (FH), we prospectively levaquin lawsuit california acid technique. The beneficial

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effects of statins on clinical events may involve mechanisms that modify endothelial dysfunction, plaque stability, thrombus formation, and inflammatory responses. There was a highly significant correlation (P less than 0.001) between Amitriptyline ( Elavil ) (r

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0.92) and nortriptyline (r 0.79) concentrations and serum antimuscarinic activity. MATERIALS, METHODS AND SUBJECTS STUDIED:. Anticholinergic activity in the serum of patients receiving maintenance

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Amitriptyline ( Elavil ) or doxepin therapy.The anticholinergic

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activity in serum of depressive patients receiving Amitriptyline ( Elavil ) (50-300 mg/day) or doxepin (50-225 mg/day) was measured using a radioreceptor assay.

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Treatment

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with Atorvastatin ( Lipitor ) reduced serum total cholesterol concentration from 310 /-29 mg/dl in a basal situation to 203 /-34 mg/dl ( P. The

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steady state serum levels of Amitriptyline ( Elavil ) and doxepin and their

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desmethylated metabolites, nortriptyline and desmethyldoxepin were measured by radioimmunoassay in the same serum samples. The study involved 31 patients with FH and 20 healthy individuals as a control group. In evaluation of excessive anticholinergic activity in patients. The method may have

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clinical applications e.g. For the first 8 weeks, the patients were on a hypolipemic diet only and for the subsequent 12 weeks, alongside the diet they were given 10 mg Atorvastatin ( Lipitor ) per day. The aim of this paper was to evaluate the effects of Atorvastatin ( Lipitor ) therapy on the erythrocyte membrane

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structure and the hypolipemic efficacy in patients with FH. Erythrocyte membrane fluidity was determined using the spin labeled method. The effect of Atorvastatin ( Lipitor ) on erythrocyte membranes and serum lipids in patients with type-2 hypercholesterolemia.BACKGROUND:. The correlation

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was less clear, although statistically significant for doxepin (r 0.42, P less than 0.05) and desmethyldoxepin (r 0.58, P less than 0.01).

Laboratory tests were carried out before and after 4 weeks and 12 weeks of the pharmacological treatment. The better correlation between serum drug levels and antimuscarinic activity in Amitriptyline ( Elavil ) than in doxepin patients is probably due to the higher affinity of Amitriptyline ( Elavil ) and its desmethylated metabolite to muscarinic receptors with the doses used in the present study. Using atropine as a standard, the antimuscarinic activity of several compounds can be measured in the serum of patients receiving drugs with anticholinergic effects or side-effects.